Education
MD, University of Patras, School of Medicine, Patras, Greece, 2000
PhD, Boston University; School of Medicine, Boston MA, 2006
Biography
Research
Our lab aims to elucidate the epigenetic mechanisms that drive human malignancies by using newly developed genetically engineered mouse models and high-throughput approaches.
1. Epigenetic progression model of pancreatic cancer: We seek to define the core epigenetic programs that co-operate with genetic alterations to drive pancreatic cancer initiation and maintenance.
2. Epigenetic regulation of Hematopoietic Stem Cells: Using new genetically engineered mouse models we are studying the role of KDM2B in leukemias and in the self-renewal and differentiation potential of hematopoietic stem cells.
Publications
- Tzatsos A*, Paskaleva P, Ferrari F, Deshpande V, Stoykova S, Contino G, Wong KK, Lan F, Trojer P, and Bardeesy N*. KDM2B controls tumorigenesis in pancreatic cancer via Polycomb-dependent and -independent transcriptional programs. J Clin Invest. 2013 Feb 1;123(2):727-39. *corresponding author
- Tzatsos A*, Paskaleva P, Lymperi S, Contino G, Stoykova S, Chen Z, Wong KK, Bardeesy N*. Lysine-specific demethylase 2B (KDM2B)-let-7-enhancer of zester homolog 2 (EZH2) pathway regulates cell cycle progression and senescence in primary cells. J Biol Chem. 2011 Sep 23;286(38):33061-9. *corresponding author
- Tzatsos A*. Raptor binds the SAIN (Shc and IRS-1 NPXY binding) domain of insulin receptor substrate-1 (IRS-1) and regulates the phosphorylation of IRS-1 at Ser-636/639 by mTOR. J Biol Chem. 2009 Aug 21;284(34):22525-34. *corresponding author
- Tzatsos A, Pfau R, Kampranis SC, Tsichlis PN. Ndy1/KDM2B immortalizes mouse embryonic fibroblasts by repressing the Ink4a/Arf locus. Proc Natl Acad Sci U S A. 2009 Feb 24;106(8):2641-6.
- Pfau R, Tzatsos A, Kampranis SC, Serebrennikova OB, Bear SE, Tsichlis PN. Members of a family of JmjC domain-containing oncoproteins immortalize embryonic fibroblasts via a JmjC domain-dependent process. Proc Natl Acad Sci U S A. 2008 Feb 12;105(6):1907-12.
- Tzatsos A, Tsichlis PN. Energy depletion inhibits phosphatidylinositol 3-kinase/Akt signaling and induces apoptosis via AMP-activated protein kinase-dependent phosphorylation of IRS-1 at Ser-794. J Biol Chem. 2007 Jun 22;282(25):18069-82.
- Tzatsos A*, Kandror KV*. Nutrients suppress phosphatidylinositol 3-kinase/Akt signaling via raptor-dependent mTOR-mediated insulin receptor substrate 1 phosphorylation. Mol Cell Biol. 2006 Jan;26(1):63-76.*corresponding author