Dr. Seto’s laboratory focuses on understanding histone deacetylase, an enzyme that epigenetically regulates how certain genes turn on or off. As the associate center director, Dr. Seto is also developing three basic science research programs that will help the center’s bid for National Cancer Institute designation: cancer biology, immunology/immunotherapy, and microbial oncology.
Research
The Seto lab is devoted to obtaining a complete understanding of the functions, mechanisms of action, and regulation of histone deacteylases (HDACs), an enzyme that catalyze the removal of acetyl groups from the lysine residues of histones. These enzymes play a pivotal role in the regulation of gene transcription and are indispensable in numerous eukaryotic biological processes involving chromatin.
Visit Dr. Seto Lab Website
Grants
NIH R01 CA240529
Regulation of anti-tumor immunity by HDAC11
06/01/2020 – 05/31/2025
NIH T32 CA247756
Cancer Biology Training Program (CBTP)
07/01/2020 – 06/30/2025
NIH R01 AI153110
Design and development of HDAC11-specific chemical inhibitors for disease treatments
03/01/2021 – 02/28/2026
King Fahd Professor of Cancer Biology
Teaching
BMSC 8210
Genes to Cells
CANC 8221
The Basic Science of Oncology
CANC 8222
Molecular Oncology and Cancer Epigenetics
BIOC 6222
Biochemical Genetics and Medicine
BIOC 6230
New Technologies in Scientific Research
Center and Institutes
GW Cancer Center
Programs
GW Cancer Center