Education
B.S., Xavier University, 2001
PhD, Indiana University School of Medicine, 2006
Biography
Research
Our lab studies the genetic and activity-dependent cues that direct proper wiring in the brain. During development, billions of neurons need to make trillions of synapses in a precise manner to mediate proper sensory perception, behaviors and cognitive processes. In many sensory systems, neurons are organized into topographic maps of space, wherein neighboring neurons monitor adjacent regions of the outside world. In associative centers, maps of different sensory modalities must be brought into register to allow for proper integration. To understand the cellular processes involved in this precise wiring, we utilize anatomical tracing methods, electrophysiology and molecular techniques in transgenic mouse models.
Publications
- Drayson LE and Triplett JW. A Chrnb3-Cre BAC transgenic mouse line for manipulation of gene expression in retinal ganglion cells. Genesis 2019 Sep;57(9):e23305.
- Kay RB, Gabreski NA, Triplett JW. Visual subcircuit-specific dysfunction and disorganization in the superior colliculus of fragile X mice. J Neurodev Disord 2018 Jun 28;10(1):23.
- Kay RB and Triplett JW. Visual neurons in the superior colliculus innervated by Islet2+ and Islet- retinal ganglion cells display distinct tuning properties. Front Neural Circuits 2017 Oct 10;11:73.
- Tikidji-Hamburyan RA, El-Ghazawi TA, Triplett JW. Novel models of visual topographic map alignment in the superior colliculus. PLoS Comput Biol 2016 Dec 27;12(12):e1005315.
- Owens MT, Feldheim DA, Stryker MP, Triplett JW. Stochastic interaction between neural activity and molecular cues in the formation of topographic maps. Neuron 2015 Sep 23;87(6):1261-73.